cortical cells — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3198L	PRE-084 hydrochloride		Sigma receptor
	PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).		Sigma receptor
T6S1418	Praeruptorin C		Antioxidant , Calcium Channel
	1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...		Antioxidant , Calcium Channel
T5S2129	Sciadopitysin		TNF , NF-κB
	Sciadopitysin may prevent the development of diabetic osteopathy, it exerts its therapeutic effects via upregulation of mitochondrial biogenesis.Sciadopitysin shows protective effects on antimycin A-induced toxicity in o...		TNF , NF-κB
T23394	SR 57227A	SR 57227 hydrochloride	5-HT Receptor
	SR 57227A (SR 57227 hydrochloride) is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 rece...		5-HT Receptor
T3486	3-MATIDA		GluR , NMDAR
	3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3...		GluR , NMDAR
T3648	Hypidone hydrochloride	YL0919	5-HT Receptor
	Hypidone hydrochloride (YL0919) is a novel antidepressant candidate with dual activity as a 5-HT1A receptor agonist and a selective serotonin reuptake inhibitor.		5-HT Receptor
T28850	SR57227A	SR 57227A,SR-57227A
	SR 57227A is a highly selective of peripheral and central 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreas...
TN2037	Paeonilactone C		Others
	Paeonilactone C significantly protects primary cultures of rat cortical cells against H2O2-induced neurotoxicity.		Others
T16155	MSN-125		Akt
	MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization in...		Akt
TCA2511	11Beta-hydroxyprogesterone		Sodium Channel
	The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone...		Sodium Channel
TN5169	Traxillaside		Others
	Traxillaside has significant neuroprotective activities against glutamate-induced toxicity in primary cultures of rat cortical cells .		Others
TN2036	Paeonilactone B	(+)-Paeonilactone B	NADPH-oxidase
	Paeonilactone B ((+)-Paeonilactone B), a monoterpenoid from Paeonilactone, has neuroprotective activity, inhibits oxidative stress, and suppresses H2O2-induced neurotoxicity in rat cortical cells.		NADPH-oxidase
TN3771	Dasycarpol		Others
	Dasycarpol(9beta-Hydroxyfraxinellone) shows significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM. Dasycarpol also shows m...		Others
T37661	LY 2886721 Hydrochloride
	Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a...
T16846	Sauristolactam	Saurolactam	Others
	Sauristolactam inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation. Sauristolactam, a natural aristolactam isolated f...		Others
T36516	RC574	RC574
	RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons...
TN3444	Aristolactam BII		HIV Protease
	Aristolactam BII exhibits antimicrobial and antiinflammatory activity, it shows significant activity towards DPPH radical scavenging and potent inhibitory effects against tyrosinase mushroom. Aristolactam BII also exerts...		HIV Protease
T37370	Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)
	Amyloid-β (25-35) (Aβ (25-35)) is an 11-residue fragment of the Aβ protein that retains the physical and biological characteristics of the full length peptide. It forms fibrils that react to thioflavin T and Congo red an...
TN5164	Trans-Hinokiresinol		IL Receptor , TNF , NOS , LTR
	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyaso...		IL Receptor , TNF , NOS , LTR
T35494	(±)11(12)-EET
	(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms C...